The NSW Government is supporting the growth of NSW’s RNA ecosystem, recognising the potential of ribonucleic acid (RNA) technology and building on NSW’s world-class research and development (R&D). This initiative is part of NSW Government’s broader commitment to advancing the health, medical, agricultural and biosecurity R&D and manufacturing sectors.
This includes supporting discovery, scale-up, commercialisation and workforce development to accelerate market entry and expansion and create new skilled jobs across the state.
In October 2021, the NSW Government announced a $96 million investment to establish a state-of-the-art RNA Research and Manufacturing Facility (the Facility) at Macquarie University. The Facility will be operated by Aurora Biosynthetics through a public-private partnership and will deliver Australia’s first open-access GMP-grade RNA manufacturing capability at research and clinical scale.
To support and activate the broader ecosystem around the Facility, the Government committed an additional $119 million over 10 years to establish the RNA R&D Initiatives Fund, administered by the Office of the Chief Scientist & Engineer (OCSE) within the NSW Premier's Department (the Department). This funding supports a range of initiatives to foster investment in RNA research and development, accelerate commercialisation, build workforce capability across the RNA value chain, and improve access to research infrastructure. This combined investment in R&D capability and infrastructure will enable RNA innovations to be scaled, trialled, and commercialised in NSW.
The RNA Pipeline Grants (RPG) is a $6 million, single round, competitive technology development and commercialisation program as part of the RNA R&D Initiatives Fund.
The RPG supports the development and commercialisation of innovative RNA therapeutics, vaccines, and related technologies (such as RNA delivery technology) with a clear manufacturing pathway —spanning applications in health, biosecurity and agriculture. The RPG aims to build a robust pipeline of RNA-based products in NSW that could be manufactured at the Facility, helping bridge the gap between discovery and scalable production. By supporting projects that are progressing toward commercial readiness and manufacturing feasibility, the RPG aims to attract future investment, increase local manufacturing and grow a globally competitive RNA ecosystem that delivers long-term health, economic and scientific benefits for the people of NSW. NSW-based manufacturing capabilities, including the RNA Facility, are central to this vision. These facilities provide scalable production capacity for RNA-based products developed through the RPG and other initiatives.
The RPG has $6 million in funding for projects ranging between $200,000 to $3 million.
Objectives
The objectives of the RPG program are to:
- support a pipeline of products that could be manufactured at the NSW RNA Research and Manufacturing Facility
- progress the development and manufacture of innovative RNA therapeutics, vaccines and related technologies – including applications in health, biosecurity and agriculture - towards commercialisation in NSW
- improve commercialisation opportunities for NSW-based start-ups and businesses through targeted support for translation and scale-up
- contribute to a globally competitive RNA ecosystem that delivers long-term economic, scientific, and social benefits for NSW, including enhanced workforce capability and sovereign manufacturing capacity.
Closing date
The closing date is 01:00 pm AEDT 16 September 2025.
Looking for assistance in applying?
At NSW Premier’s Department, we are committed to diversity, equity, and inclusion. We encourage people with disability to apply. If you are a person with disability and require more information on adjustments and assistance to apply, please contact us at grants@chiefscientist.nsw.gov.au. Assistance in completing this application can be found at Communities and Justice, People with Disability Australia or Legal Aid.
If you are an Aboriginal or Torres Strait Islander, check out Aboriginal Affairs or your country’s Aboriginal Corporation to get assistance in the preparations of applications and grant program processes.